I posted this on the old site, but it’s worth posting again due to the release of Windows 7. This Microsoft KB article outlines the recommended configuration for Anti-Virus programs on almost all versions of Windows. A must see for Administrators!
“This article contains recommendations that may help you protect a computer that is running Windows Server 2008 R2, Windows Server 2008, Windows Server 2003, Microsoft Windows 2000, Windows XP, Windows Vista, or Windows 7 from viruses. This article also contains information to help you minimize the effect of antivirus software on system and network performance.”